Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations

Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2 also associates with Mfn1, but the functional significanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Detmer, Scott A., Chan, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063976/
https://www.ncbi.nlm.nih.gov/pubmed/17296794
http://dx.doi.org/10.1083/jcb.200611080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063976/
https://www.ncbi.nlm.nih.gov/pubmed/17296794
http://dx.doi.org/10.1083/jcb.200611080

Ejemplares similares