Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C–null mice are therefore proposed to totally lack granzyme B activity and perforin-dependent cytotoxicity. Surprisingly...

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Detalles Bibliográficos
Autores principales: Sutton, Vivien R., Waterhouse, Nigel J., Browne, Kylie A., Sedelies, Karin, Ciccone, Annette, Anthony, Desiree, Koskinen, Aulikki, Mullbacher, Arno, Trapani, Joseph A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063978/
https://www.ncbi.nlm.nih.gov/pubmed/17283185
http://dx.doi.org/10.1083/jcb.200609077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063978/
https://www.ncbi.nlm.nih.gov/pubmed/17283185
http://dx.doi.org/10.1083/jcb.200609077

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