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Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C–null mice are therefore proposed to totally lack granzyme B activity and perforin-dependent cytotoxicity. Surprisingly...

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Detalles Bibliográficos
Autores principales:	Sutton, Vivien R., Waterhouse, Nigel J., Browne, Kylie A., Sedelies, Karin, Ciccone, Annette, Anthony, Desiree, Koskinen, Aulikki, Mullbacher, Arno, Trapani, Joseph A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063978/ https://www.ncbi.nlm.nih.gov/pubmed/17283185 http://dx.doi.org/10.1083/jcb.200609077

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