DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

DNA methylation plays a central role in the epigenetic regulation of gene expression in vertebrates. Genetic and biochemical data indicated that DNA methyltransferase 1 (Dnmt1) is indispensable for the maintenance of DNA methylation patterns in mice, but targeting of the DNMT1 locus in human HCT116...

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Detalles Bibliográficos
Autores principales: Spada, Fabio, Haemmer, Andrea, Kuch, David, Rothbauer, Ulrich, Schermelleh, Lothar, Kremmer, Elisabeth, Carell, Thomas, Längst, Gernot, Leonhardt, Heinrich
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064015/
https://www.ncbi.nlm.nih.gov/pubmed/17312023
http://dx.doi.org/10.1083/jcb.200610062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064015/
https://www.ncbi.nlm.nih.gov/pubmed/17312023
http://dx.doi.org/10.1083/jcb.200610062

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