Notch signaling is necessary for epithelial growth arrest by TGF-β

Transforming growth factor β (TGF-β) and Notch act as tumor suppressors by inhibiting epithelial cell proliferation. TGF-β additionally promotes tumor invasiveness and metastasis, whereas Notch supports oncogenic growth. We demonstrate that TGF-β and ectopic Notch1 receptor cooperatively arrest epit...

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Detalles Bibliográficos
Autores principales: Niimi, Hideki, Pardali, Katerina, Vanlandewijck, Michael, Heldin, Carl-Henrik, Moustakas, Aristidis
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064026/
https://www.ncbi.nlm.nih.gov/pubmed/17325209
http://dx.doi.org/10.1083/jcb.200612129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064026/
https://www.ncbi.nlm.nih.gov/pubmed/17325209
http://dx.doi.org/10.1083/jcb.200612129

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