Centromeric chromatin gets loaded

Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at...

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Detalles Bibliográficos
Autores principales: Carroll, Christopher W., Straight, Aaron F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064045/
https://www.ncbi.nlm.nih.gov/pubmed/17339381
http://dx.doi.org/10.1083/jcb.200702020
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author Carroll, Christopher W.
Straight, Aaron F.
author_facet Carroll, Christopher W.
Straight, Aaron F.
author_sort Carroll, Christopher W.
collection PubMed
description Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at centromeres during the cell division cycle and identify an evolutionally conserved protein required for CENP-A deposition. Together, these studies advance our understanding of centromeric chromatin assembly and provide a framework for investigating the molecular mechanisms that underlie the centromere-specific loading of CENP-A.
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spelling pubmed-20640452007-11-29 Centromeric chromatin gets loaded Carroll, Christopher W. Straight, Aaron F. J Cell Biol Reviews Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at centromeres during the cell division cycle and identify an evolutionally conserved protein required for CENP-A deposition. Together, these studies advance our understanding of centromeric chromatin assembly and provide a framework for investigating the molecular mechanisms that underlie the centromere-specific loading of CENP-A. The Rockefeller University Press 2007-03-12 /pmc/articles/PMC2064045/ /pubmed/17339381 http://dx.doi.org/10.1083/jcb.200702020 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Carroll, Christopher W.
Straight, Aaron F.
Centromeric chromatin gets loaded
title Centromeric chromatin gets loaded
title_full Centromeric chromatin gets loaded
title_fullStr Centromeric chromatin gets loaded
title_full_unstemmed Centromeric chromatin gets loaded
title_short Centromeric chromatin gets loaded
title_sort centromeric chromatin gets loaded
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064045/
https://www.ncbi.nlm.nih.gov/pubmed/17339381
http://dx.doi.org/10.1083/jcb.200702020
work_keys_str_mv AT carrollchristopherw centromericchromatingetsloaded
AT straightaaronf centromericchromatingetsloaded

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