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Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vitro and in vivo. Syk(−/−) osteoclasts fail to organize their cytoskeleton, and, as such, their bone-resorptive capacity is arrested. This defect results in increased skeletal mass in Syk(−/−) embryos a...

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Detalles Bibliográficos
Autores principales:	Zou, Wei, Kitaura, Hideki, Reeve, Jennifer, Long, Fanxin, Tybulewicz, Victor L.J., Shattil, Sanford J., Ginsberg, Mark H., Ross, F. Patrick, Teitelbaum, Steven L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064061/ https://www.ncbi.nlm.nih.gov/pubmed/17353363 http://dx.doi.org/10.1083/jcb.200611083

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