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The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for Bcl-x and affects its alternative splicing. Depletion of Sam68 by RNA interference caused accumulation of antiapoptotic Bcl-x...

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Detalles Bibliográficos
Autores principales:	Paronetto, Maria Paola, Achsel, Tilman, Massiello, Autumn, Chalfant, Charles E., Sette, Claudio
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064079/ https://www.ncbi.nlm.nih.gov/pubmed/17371836 http://dx.doi.org/10.1083/jcb.200701005

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