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Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
Spastin, an AAA ATPase mutated in the neurodegenerative disease hereditary spastic paraplegia, severs microtubules. Many other AAA proteins form ring-shaped hexamers and contain pore loops, which project into the ring's central cavity and act as ratchets that pull on target proteins, leading, i...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064084/ https://www.ncbi.nlm.nih.gov/pubmed/17389232 http://dx.doi.org/10.1083/jcb.200610072 |