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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

Toll-like receptors (TLRs) sense the presence of microbial and viral pathogens by signal transduction mechanisms that remain to be fully elucidated. A single point mutation (H412R) in the polytopic endoplasmic reticulum (ER)–resident membrane protein UNC93B abolishes signaling via TLR3, 7, and 9. We...

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Detalles Bibliográficos
Autores principales:	Brinkmann, Melanie M., Spooner, Eric, Hoebe, Kasper, Beutler, Bruce, Ploegh, Hidde L., Kim, You-Me
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064135/ https://www.ncbi.nlm.nih.gov/pubmed/17452530 http://dx.doi.org/10.1083/jcb.200612056

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