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Accumulation of Mad2–Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae

The spindle assembly checkpoint (SAC) coordinates mitotic progression with sister chromatid alignment. In mitosis, the checkpoint machinery accumulates at kinetochores, which are scaffolds devoted to microtubule capture. The checkpoint protein Mad2 (mitotic arrest deficient 2) adopts two conformatio...

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Detalles Bibliográficos
Autores principales:	Nezi, Luigi, Rancati, Giulia, De Antoni, Anna, Pasqualato, Sebastiano, Piatti, Simonetta, Musacchio, Andrea
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064158/ https://www.ncbi.nlm.nih.gov/pubmed/16818718 http://dx.doi.org/10.1083/jcb.200602109

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