Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase–mediated apoptosis of HeLa cells

We show that caspase-3 cleaves Cdc6 at D(290)/S and D(442)/G sites, producing p32-tCdc6 (truncated Cdc6) and p49-tCdc6, respectively, during etoposide- or tumor necrosis factor (TNF)-α–induced apoptosis. The expression of these tCdc6 proteins, p32- and p49-tCdc6, promotes etoposide-induced apoptosis...

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Detalles Bibliográficos
Autores principales: Yim, Hyungshin, Hwang, In Sun, Choi, Joon-Seok, Chun, Kwang-Hoon, Jin, Ying Hua, Ham, Young-Mi, Lee, Kwang Youl, Lee, Seung Ki
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064166/
https://www.ncbi.nlm.nih.gov/pubmed/16801388
http://dx.doi.org/10.1083/jcb.200509141

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