An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling

Focal adhesion kinase (FAK) transduces cell adhesion to the extracellular matrix into proliferative signals. We show that FAK overexpression induced proliferation in endothelial cells, which are normally growth arrested by limited adhesion. Interestingly, displacement of FAK from adhesions by using...

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Detalles Bibliográficos
Autores principales: Pirone, Dana M., Liu, Wendy F., Ruiz, Sami Alom, Gao, Lin, Raghavan, Srivatsan, Lemmon, Christopher A., Romer, Lewis H., Chen, Christopher S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064187/
https://www.ncbi.nlm.nih.gov/pubmed/16847103
http://dx.doi.org/10.1083/jcb.200510062

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