Interactions between heparan sulfate and proteins: the concept of specificity

Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and...

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Detalles Bibliográficos
Autores principales: Kreuger, Johan, Spillmann, Dorothe, Li, Jin-ping, Lindahl, Ulf
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064228/
https://www.ncbi.nlm.nih.gov/pubmed/16880267
http://dx.doi.org/10.1083/jcb.200604035
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author Kreuger, Johan
Spillmann, Dorothe
Li, Jin-ping
Lindahl, Ulf
author_facet Kreuger, Johan
Spillmann, Dorothe
Li, Jin-ping
Lindahl, Ulf
author_sort Kreuger, Johan
collection PubMed
description Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS–protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.
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spelling pubmed-20642282007-11-29 Interactions between heparan sulfate and proteins: the concept of specificity Kreuger, Johan Spillmann, Dorothe Li, Jin-ping Lindahl, Ulf J Cell Biol Reviews Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS–protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure. The Rockefeller University Press 2006-07-31 /pmc/articles/PMC2064228/ /pubmed/16880267 http://dx.doi.org/10.1083/jcb.200604035 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Kreuger, Johan
Spillmann, Dorothe
Li, Jin-ping
Lindahl, Ulf
Interactions between heparan sulfate and proteins: the concept of specificity
title Interactions between heparan sulfate and proteins: the concept of specificity
title_full Interactions between heparan sulfate and proteins: the concept of specificity
title_fullStr Interactions between heparan sulfate and proteins: the concept of specificity
title_full_unstemmed Interactions between heparan sulfate and proteins: the concept of specificity
title_short Interactions between heparan sulfate and proteins: the concept of specificity
title_sort interactions between heparan sulfate and proteins: the concept of specificity
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064228/
https://www.ncbi.nlm.nih.gov/pubmed/16880267
http://dx.doi.org/10.1083/jcb.200604035
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AT lijinping interactionsbetweenheparansulfateandproteinstheconceptofspecificity
AT lindahlulf interactionsbetweenheparansulfateandproteinstheconceptofspecificity

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