The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

Aspergillus fumigatus infections cause high levels of morbidity and mortality in immunocompromised patients. Gliotoxin (GT), a secondary metabolite, is cytotoxic for mammalian cells, but the molecular basis and biological relevance of this toxicity remain speculative. We show that GT induces apoptot...

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Detalles Bibliográficos
Autores principales: Pardo, Julian, Urban, Christin, Galvez, Eva M., Ekert, Paul G., Müller, Uwe, Kwon-Chung, June, Lobigs, Mario, Müllbacher, Arno, Wallich, Reinhard, Borner, Christoph, Simon, Markus M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064257/
https://www.ncbi.nlm.nih.gov/pubmed/16893972
http://dx.doi.org/10.1083/jcb.200604044

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