When sparks get old

Sparks are transient local elevations of Ca ion concentration observed in different types of muscle cells. Such local Ca(2+) signals can be provoked in skeletal muscle cells by altering the osmotic pressure of the extracellular solution. In this issue, Weisleder et al. (see p. 639) demonstrate that...

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Detalles Bibliográficos
Autor principal: Melzer, Werner
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064303/
https://www.ncbi.nlm.nih.gov/pubmed/16943178
http://dx.doi.org/10.1083/jcb.200608014
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author Melzer, Werner
author_facet Melzer, Werner
author_sort Melzer, Werner
collection PubMed
description Sparks are transient local elevations of Ca ion concentration observed in different types of muscle cells. Such local Ca(2+) signals can be provoked in skeletal muscle cells by altering the osmotic pressure of the extracellular solution. In this issue, Weisleder et al. (see p. 639) demonstrate that the Ca(2+) response to osmotic stress is substantially altered in aged muscle. The study presents evidence for a link between this finding and a reduced expression of mitsugumin 29 (MG29), a small membrane protein of the sarcoplasmic reticulum (SR).
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spelling pubmed-20643032007-11-29 When sparks get old Melzer, Werner J Cell Biol Reviews Sparks are transient local elevations of Ca ion concentration observed in different types of muscle cells. Such local Ca(2+) signals can be provoked in skeletal muscle cells by altering the osmotic pressure of the extracellular solution. In this issue, Weisleder et al. (see p. 639) demonstrate that the Ca(2+) response to osmotic stress is substantially altered in aged muscle. The study presents evidence for a link between this finding and a reduced expression of mitsugumin 29 (MG29), a small membrane protein of the sarcoplasmic reticulum (SR). The Rockefeller University Press 2006-08-28 /pmc/articles/PMC2064303/ /pubmed/16943178 http://dx.doi.org/10.1083/jcb.200608014 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Melzer, Werner
When sparks get old
title When sparks get old
title_full When sparks get old
title_fullStr When sparks get old
title_full_unstemmed When sparks get old
title_short When sparks get old
title_sort when sparks get old
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064303/
https://www.ncbi.nlm.nih.gov/pubmed/16943178
http://dx.doi.org/10.1083/jcb.200608014
work_keys_str_mv AT melzerwerner whensparksgetold

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