Cargando…
Specificity in reactive oxidant signaling: think globally, act locally
Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants i...
Autor principal: | |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064304/ https://www.ncbi.nlm.nih.gov/pubmed/16923830 http://dx.doi.org/10.1083/jcb.200605036 |
_version_ | 1782137507286089728 |
---|---|
author | Terada, Lance S. |
author_facet | Terada, Lance S. |
author_sort | Terada, Lance S. |
collection | PubMed |
description | Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling. |
format | Text |
id | pubmed-2064304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-20643042007-11-29 Specificity in reactive oxidant signaling: think globally, act locally Terada, Lance S. J Cell Biol Reviews Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling. The Rockefeller University Press 2006-08-28 /pmc/articles/PMC2064304/ /pubmed/16923830 http://dx.doi.org/10.1083/jcb.200605036 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Terada, Lance S. Specificity in reactive oxidant signaling: think globally, act locally |
title | Specificity in reactive oxidant signaling: think globally, act locally |
title_full | Specificity in reactive oxidant signaling: think globally, act locally |
title_fullStr | Specificity in reactive oxidant signaling: think globally, act locally |
title_full_unstemmed | Specificity in reactive oxidant signaling: think globally, act locally |
title_short | Specificity in reactive oxidant signaling: think globally, act locally |
title_sort | specificity in reactive oxidant signaling: think globally, act locally |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064304/ https://www.ncbi.nlm.nih.gov/pubmed/16923830 http://dx.doi.org/10.1083/jcb.200605036 |
work_keys_str_mv | AT teradalances specificityinreactiveoxidantsignalingthinkgloballyactlocally |