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Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore
The eukaryotic spindle assembly checkpoint (SAC) monitors microtubule attachment to kinetochores and prevents anaphase onset until all kinetochores are aligned on the metaphase plate. In higher eukaryotes, cytoplasmic dynein is involved in silencing the SAC by removing the checkpoint proteins Mad2 a...
Autores principales: | Griffis, Eric R., Stuurman, Nico, Vale, Ronald D. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064361/ https://www.ncbi.nlm.nih.gov/pubmed/17576797 http://dx.doi.org/10.1083/jcb.200702062 |
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