The Q(o) site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1α (HIF-1α) protein. How cells transduce hypoxic signals to stabilize the HIF-1α protein remains unresolved. We demonstrate that cells deficient in the complex III subunit...

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Detalles Bibliográficos
Autores principales: Bell, Eric L., Klimova, Tatyana A., Eisenbart, James, Moraes, Carlos T., Murphy, Michael P., Budinger, G.R. Scott, Chandel, Navdeep S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064363/
https://www.ncbi.nlm.nih.gov/pubmed/17562787
http://dx.doi.org/10.1083/jcb.200609074

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