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The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division

We identify a mitochondrial E3 ubiquitin ligase, MARCH5, as a critical regulator of mitochondrial fission. MARCH5 RING mutants and MARCH5 RNA interference induce an abnormal elongation and interconnection of mitochondria indicative of an inhibition of mitochondrial division. The aberrant mitochondri...

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Detalles Bibliográficos
Autores principales:	Karbowski, Mariusz, Neutzner, Albert, Youle, Richard J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064424/ https://www.ncbi.nlm.nih.gov/pubmed/17606867 http://dx.doi.org/10.1083/jcb.200611064

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