Cargando…

A collective form of cell death requires homeodomain interacting protein kinase

We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective “suicide waves” promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controll...

Descripción completa

Detalles Bibliográficos
Autores principales: Link, Nichole, Chen, Po, Lu, Wan-Jin, Pogue, Kristi, Chuong, Amy, Mata, Miguel, Checketts, Joshua, Abrams, John M.
Formato: Texto
Lenguaje:English
Publicado: Rockefeller University Press|1 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064464/
https://www.ncbi.nlm.nih.gov/pubmed/17682052
http://dx.doi.org/10.1083/jcb.200702125
_version_ 1782137544046018560
author Link, Nichole
Chen, Po
Lu, Wan-Jin
Pogue, Kristi
Chuong, Amy
Mata, Miguel
Checketts, Joshua
Abrams, John M.
author_facet Link, Nichole
Chen, Po
Lu, Wan-Jin
Pogue, Kristi
Chuong, Amy
Mata, Miguel
Checketts, Joshua
Abrams, John M.
author_sort Link, Nichole
collection PubMed
description We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective “suicide waves” promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers.
format Text
id pubmed-2064464
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Rockefeller University Press|1
record_format MEDLINE/PubMed
spelling pubmed-20644642008-02-13 A collective form of cell death requires homeodomain interacting protein kinase Link, Nichole Chen, Po Lu, Wan-Jin Pogue, Kristi Chuong, Amy Mata, Miguel Checketts, Joshua Abrams, John M. J Cell Biol Research Articles We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective “suicide waves” promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers. Rockefeller University Press|1 2007-08-13 /pmc/articles/PMC2064464/ /pubmed/17682052 http://dx.doi.org/10.1083/jcb.200702125 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Link, Nichole
Chen, Po
Lu, Wan-Jin
Pogue, Kristi
Chuong, Amy
Mata, Miguel
Checketts, Joshua
Abrams, John M.
A collective form of cell death requires homeodomain interacting protein kinase
title A collective form of cell death requires homeodomain interacting protein kinase
title_full A collective form of cell death requires homeodomain interacting protein kinase
title_fullStr A collective form of cell death requires homeodomain interacting protein kinase
title_full_unstemmed A collective form of cell death requires homeodomain interacting protein kinase
title_short A collective form of cell death requires homeodomain interacting protein kinase
title_sort collective form of cell death requires homeodomain interacting protein kinase
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064464/
https://www.ncbi.nlm.nih.gov/pubmed/17682052
http://dx.doi.org/10.1083/jcb.200702125
work_keys_str_mv AT linknichole acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT chenpo acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT luwanjin acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT poguekristi acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT chuongamy acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT matamiguel acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT checkettsjoshua acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT abramsjohnm acollectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT linknichole collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT chenpo collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT luwanjin collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT poguekristi collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT chuongamy collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT matamiguel collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT checkettsjoshua collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase
AT abramsjohnm collectiveformofcelldeathrequireshomeodomaininteractingproteinkinase