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A collective form of cell death requires homeodomain interacting protein kinase
We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective “suicide waves” promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controll...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press|1
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064464/ https://www.ncbi.nlm.nih.gov/pubmed/17682052 http://dx.doi.org/10.1083/jcb.200702125 |
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author | Link, Nichole Chen, Po Lu, Wan-Jin Pogue, Kristi Chuong, Amy Mata, Miguel Checketts, Joshua Abrams, John M. |
author_facet | Link, Nichole Chen, Po Lu, Wan-Jin Pogue, Kristi Chuong, Amy Mata, Miguel Checketts, Joshua Abrams, John M. |
author_sort | Link, Nichole |
collection | PubMed |
description | We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective “suicide waves” promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers. |
format | Text |
id | pubmed-2064464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Rockefeller University Press|1 |
record_format | MEDLINE/PubMed |
spelling | pubmed-20644642008-02-13 A collective form of cell death requires homeodomain interacting protein kinase Link, Nichole Chen, Po Lu, Wan-Jin Pogue, Kristi Chuong, Amy Mata, Miguel Checketts, Joshua Abrams, John M. J Cell Biol Research Articles We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective “suicide waves” promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers. Rockefeller University Press|1 2007-08-13 /pmc/articles/PMC2064464/ /pubmed/17682052 http://dx.doi.org/10.1083/jcb.200702125 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Research Articles Link, Nichole Chen, Po Lu, Wan-Jin Pogue, Kristi Chuong, Amy Mata, Miguel Checketts, Joshua Abrams, John M. A collective form of cell death requires homeodomain interacting protein kinase |
title | A collective form of cell death requires homeodomain interacting protein kinase |
title_full | A collective form of cell death requires homeodomain interacting protein kinase |
title_fullStr | A collective form of cell death requires homeodomain interacting protein kinase |
title_full_unstemmed | A collective form of cell death requires homeodomain interacting protein kinase |
title_short | A collective form of cell death requires homeodomain interacting protein kinase |
title_sort | collective form of cell death requires homeodomain interacting protein kinase |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064464/ https://www.ncbi.nlm.nih.gov/pubmed/17682052 http://dx.doi.org/10.1083/jcb.200702125 |
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