Putting the glue in glia: Necls mediate Schwann cell–axon adhesion

Interactions between Schwann cells and axons are critical for the development and function of myelinated axons. Two recent studies (see Maurel et al. on p. 861 of this issue; Spiegel et al., 2007) report that the nectin-like (Necl) proteins Necl-1 and -4 are internodal adhesion molecules that are cr...

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Detalles Bibliográficos
Autores principales: Perlin, Julie R., Talbot, William S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064536/
https://www.ncbi.nlm.nih.gov/pubmed/17724116
http://dx.doi.org/10.1083/jcb.200708019
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author Perlin, Julie R.
Talbot, William S.
author_facet Perlin, Julie R.
Talbot, William S.
author_sort Perlin, Julie R.
collection PubMed
description Interactions between Schwann cells and axons are critical for the development and function of myelinated axons. Two recent studies (see Maurel et al. on p. 861 of this issue; Spiegel et al., 2007) report that the nectin-like (Necl) proteins Necl-1 and -4 are internodal adhesion molecules that are critical for myelination. These studies suggest that Necl proteins mediate a specific interaction between Schwann cells and axons that allows proper communication of the signals that trigger myelination.
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spelling pubmed-20645362008-02-27 Putting the glue in glia: Necls mediate Schwann cell–axon adhesion Perlin, Julie R. Talbot, William S. J Cell Biol Reviews Interactions between Schwann cells and axons are critical for the development and function of myelinated axons. Two recent studies (see Maurel et al. on p. 861 of this issue; Spiegel et al., 2007) report that the nectin-like (Necl) proteins Necl-1 and -4 are internodal adhesion molecules that are critical for myelination. These studies suggest that Necl proteins mediate a specific interaction between Schwann cells and axons that allows proper communication of the signals that trigger myelination. The Rockefeller University Press 2007-08-27 /pmc/articles/PMC2064536/ /pubmed/17724116 http://dx.doi.org/10.1083/jcb.200708019 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Perlin, Julie R.
Talbot, William S.
Putting the glue in glia: Necls mediate Schwann cell–axon adhesion
title Putting the glue in glia: Necls mediate Schwann cell–axon adhesion
title_full Putting the glue in glia: Necls mediate Schwann cell–axon adhesion
title_fullStr Putting the glue in glia: Necls mediate Schwann cell–axon adhesion
title_full_unstemmed Putting the glue in glia: Necls mediate Schwann cell–axon adhesion
title_short Putting the glue in glia: Necls mediate Schwann cell–axon adhesion
title_sort putting the glue in glia: necls mediate schwann cell–axon adhesion
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064536/
https://www.ncbi.nlm.nih.gov/pubmed/17724116
http://dx.doi.org/10.1083/jcb.200708019
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