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Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
The dynamin-related protein Opa1 is localized to the mitochondrial intermembrane space, where it facilitates fusion between mitochondria. Apoptosis causes Opa1 release into the cytosol and causes mitochondria to fragment. Loss of mitochondrial membrane potential also causes mitochondrial fragmentati...
Autores principales: | Griparic, Lorena, Kanazawa, Takayuki, van der Bliek, Alexander M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064541/ https://www.ncbi.nlm.nih.gov/pubmed/17709430 http://dx.doi.org/10.1083/jcb.200704112 |
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