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How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation
How the integrin head transitions to the high-affinity conformation is debated. Although experiments link activation with the opening of the hinge angle between the βA and hybrid domains in the ligand-binding headpiece, this hinge is closed in the liganded α(v)β(3) integrin crystal structure. We rep...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064575/ https://www.ncbi.nlm.nih.gov/pubmed/17060501 http://dx.doi.org/10.1083/jcb.200602071 |