Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains

In myotonic dystrophy type 1 (DM1), triplet repeat expansion in the 3′ untranslated region of dystrophia myotonica protein kinase (DMPK) causes the nuclear retention of mutant messenger RNA (mRNA). Although the DMPK gene locus positions precisely at the outer edge of a factor-rich SC-35 domain, the...

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Detalles Bibliográficos
Autores principales: Smith, Kelly P., Byron, Meg, Johnson, Carol, Xing, Yigong, Lawrence, Jeanne B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064620/
https://www.ncbi.nlm.nih.gov/pubmed/17846170
http://dx.doi.org/10.1083/jcb.200706048

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