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SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IκB-α/NF-κB

Sensitive to apoptosis gene (SAG)/regulator of cullins-2–Skp1-cullin–F-box protein (SCF) E3 ubiquitin ligase regulates cellular functions through ubiquitination and degradation of protein substrates. We report that, when expressed in mouse epidermis driven by the K14 promoter, SAG inhibited TPA-indu...

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Detalles Bibliográficos
Autores principales:	Gu, Qingyang, Bowden, G. Tim, Normolle, Daniel, Sun, Yi
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064624/ https://www.ncbi.nlm.nih.gov/pubmed/17846172 http://dx.doi.org/10.1083/jcb.200612067

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