Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind directly to p-STAT5A and are required to promote its nuclear translocation. Using permeabilized cells, w...

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Detalles Bibliográficos
Autores principales: Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, Hatori, Tomonori, Tsuchiya, Akiho, Kiyono, Mari, Nosaka, Tetsuya, Nakajima, Hideaki, Williams, David A., Kitamura, Toshio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064703/
https://www.ncbi.nlm.nih.gov/pubmed/17178910
http://dx.doi.org/10.1083/jcb.200604073

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