Cargando…

β4 integrin activates a Shp2–Src signaling pathway that sustains HGF-induced anchorage-independent growth

Despite being a cell–matrix adhesion molecule, β4 integrin can prompt the multiplication of neoplastic cells dislodged from their substrates (anchorage-independent growth). However, the molecular events underlying this atypical behavior remain partly unexplored. We found that activation of the Met r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bertotti, Andrea, Comoglio, Paolo M., Trusolino, Livio
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064708/ https://www.ncbi.nlm.nih.gov/pubmed/17158954 http://dx.doi.org/10.1083/jcb.200605114

Ejemplares similares

Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression
por: Desgrosellier, Jay S, et al.
Publicado: (2009)

Integrins, Oncogenes, and Anchorage Independence
por: Schwartz, Martin Alexander
Publicado: (1997)

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth
por: DeRita, Rachel M., et al.
Publicado: (2019)

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion
por: Sachdev, Sanjay, et al.
Publicado: (2009)

An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth
por: Dohn, Michael R., et al.
Publicado: (2009)

The Met oncogene and basal-like breast cancer: another culprit to watch out for?
por: Gastaldi, Stefania, et al.
Publicado: (2010)

Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion.
por: Empereur, S., et al.
Publicado: (1997)

v-src transformation of rat embryo fibroblasts. Inefficient conversion to anchorage-independent growth involves heterogeneity of primary cultures
Publicado: (1994)

Barium Promotes Anchorage-Independent Growth and Invasion of Human HaCaT Keratinocytes via Activation of c-SRC Kinase
por: Thang, Nguyen Dinh, et al.
Publicado: (2011)

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
por: Corso, Simona, et al.
Publicado: (2010)

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals
por: Lupo, Barbara, et al.
Publicado: (2016)

Suppression of anchorage-independent growth after gene transfection.
por: Winterbourne, D. J., et al.
Publicado: (1993)

ROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
por: Lazzari, Luca, et al.
Publicado: (2013)

HGF and MET: From Brain Development to Neurological Disorders
por: Desole, Claudia, et al.
Publicado: (2021)

Growth Factor–dependent Activation of αvβ3 Integrin in Normal Epithelial Cells: Implications for Tumor Invasion
por: Trusolino, Livio, et al.
Publicado: (1998)

Rac1‐mediated sustained β4 integrin level develops reattachment ability of breast cancer cells after anchorage loss
por: Mori, Kazunori, et al.
Publicado: (2021)

Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin β4 axis
por: Cheng, Yu-Che, et al.
Publicado: (2020)

MicroRNA 483‐3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis
por: Candiello, Ermes, et al.
Publicado: (2023)

Conversion of monocytes to cells capable of anchorage-independent growth in vitro
Publicado: (1981)

HGF Accelerates Wound Healing by Promoting the Dedifferentiation of Epidermal Cells through β (1)-Integrin/ILK Pathway
por: Li, Jin-Feng, et al.
Publicado: (2013)

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors
por: Mira, Alessia, et al.
Publicado: (2017)

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells
por: Picco, Gabriele, et al.
Publicado: (2015)

G1/S control of anchorage-independent growth in the fibroblast cell cycle
Publicado: (1991)

Anchorage independent growth and plasminogen activator production by bovine endothelial cells
Publicado: (1980)

Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles.
por: Lin, X, et al.
Publicado: (1994)

Reductive carboxylation supports redox homeostasis during anchorage-independent growth
por: Jiang, Lei, et al.
Publicado: (2016)

CEACAM1-4L Promotes Anchorage-Independent Growth in Melanoma
por: Löffek, Stefanie, et al.
Publicado: (2015)

The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer
por: Lee, Han Yeoung, et al.
Publicado: (2021)

MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk
por: Modica, Chiara, et al.
Publicado: (2018)

Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase
por: Anselmi, Massimiliano, et al.
Publicado: (2020)

WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma
por: Arensman, Michael D., et al.
Publicado: (2013)

Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors
por: Zahir, Nastaran, et al.
Publicado: (2003)

EGAsubmitter: A software to automate submission of nucleic acid sequencing data to the European Genome-phenome Archive
por: Viviani, Marco, et al.
Publicado: (2023)

Ligand-Independent EGFR Activation by Anchorage-Stimulated Src Promotes Cancer Cell Proliferation and Cetuximab Resistance via ErbB3 Phosphorylation
por: Nozaki, Masami, et al.
Publicado: (2019)

Mesothelial cells stimulate the anchorage-independent growth of human ovarian tumour cells.
por: Wilson, A. P.
Publicado: (1989)

OCT4B Isoform Promotes Anchorage-Independent Growth of Glioblastoma Cells
por: Choi, Sang-Hun, et al.
Publicado: (2019)

Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
por: Hervieu, Alexia, et al.
Publicado: (2020)

Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma
por: Hidmi, Sana’, et al.
Publicado: (2023)

β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
por: Defilippi, Paola, et al.
Publicado: (2005)

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment
por: Stefanski, Adrianne L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l5qb7aapsnhsum8o09tpl430sm