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Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin

Given their accessibility, multipotent skin-derived cells might be useful for future cell replacement therapies. We describe the isolation of multipotent stem cell–like cells from the adult trunk skin of mice and humans that express the neural crest stem cell markers p75 and Sox10 and display extens...

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Autores principales: Wong, Christine E., Paratore, Christian, Dours-Zimmermann, María T., Rochat, Ariane, Pietri, Thomas, Suter, Ueli, Zimmermann, Dieter R., Dufour, Sylvie, Thiery, Jean Paul, Meijer, Dies, Beermann, Friedrich, Barrandon, Yann, Sommer, Lukas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064709/
https://www.ncbi.nlm.nih.gov/pubmed/17158956
http://dx.doi.org/10.1083/jcb.200606062
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author Wong, Christine E.
Paratore, Christian
Dours-Zimmermann, María T.
Rochat, Ariane
Pietri, Thomas
Suter, Ueli
Zimmermann, Dieter R.
Dufour, Sylvie
Thiery, Jean Paul
Meijer, Dies
Beermann, Friedrich
Barrandon, Yann
Sommer, Lukas
author_facet Wong, Christine E.
Paratore, Christian
Dours-Zimmermann, María T.
Rochat, Ariane
Pietri, Thomas
Suter, Ueli
Zimmermann, Dieter R.
Dufour, Sylvie
Thiery, Jean Paul
Meijer, Dies
Beermann, Friedrich
Barrandon, Yann
Sommer, Lukas
author_sort Wong, Christine E.
collection PubMed
description Given their accessibility, multipotent skin-derived cells might be useful for future cell replacement therapies. We describe the isolation of multipotent stem cell–like cells from the adult trunk skin of mice and humans that express the neural crest stem cell markers p75 and Sox10 and display extensive self-renewal capacity in sphere cultures. To determine the origin of these cells, we genetically mapped the fate of neural crest cells in face and trunk skin of mouse. In whisker follicles of the face, many mesenchymal structures are neural crest derived and appear to contain cells with sphere-forming potential. In the trunk skin, however, sphere-forming neural crest–derived cells are restricted to the glial and melanocyte lineages. Thus, self-renewing cells in the adult skin can be obtained from several neural crest derivatives, and these are of distinct nature in face and trunk skin. These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin.
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spelling pubmed-20647092007-11-29 Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin Wong, Christine E. Paratore, Christian Dours-Zimmermann, María T. Rochat, Ariane Pietri, Thomas Suter, Ueli Zimmermann, Dieter R. Dufour, Sylvie Thiery, Jean Paul Meijer, Dies Beermann, Friedrich Barrandon, Yann Sommer, Lukas J Cell Biol Research Articles Given their accessibility, multipotent skin-derived cells might be useful for future cell replacement therapies. We describe the isolation of multipotent stem cell–like cells from the adult trunk skin of mice and humans that express the neural crest stem cell markers p75 and Sox10 and display extensive self-renewal capacity in sphere cultures. To determine the origin of these cells, we genetically mapped the fate of neural crest cells in face and trunk skin of mouse. In whisker follicles of the face, many mesenchymal structures are neural crest derived and appear to contain cells with sphere-forming potential. In the trunk skin, however, sphere-forming neural crest–derived cells are restricted to the glial and melanocyte lineages. Thus, self-renewing cells in the adult skin can be obtained from several neural crest derivatives, and these are of distinct nature in face and trunk skin. These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin. The Rockefeller University Press 2006-12-18 /pmc/articles/PMC2064709/ /pubmed/17158956 http://dx.doi.org/10.1083/jcb.200606062 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Wong, Christine E.
Paratore, Christian
Dours-Zimmermann, María T.
Rochat, Ariane
Pietri, Thomas
Suter, Ueli
Zimmermann, Dieter R.
Dufour, Sylvie
Thiery, Jean Paul
Meijer, Dies
Beermann, Friedrich
Barrandon, Yann
Sommer, Lukas
Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
title Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
title_full Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
title_fullStr Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
title_full_unstemmed Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
title_short Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
title_sort neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064709/
https://www.ncbi.nlm.nih.gov/pubmed/17158956
http://dx.doi.org/10.1083/jcb.200606062
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