Cargando…

Rhamm(−/−) fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair

Rhamm (receptor for hyaluronan-mediated motility) is an hyaluronan binding protein with limited expression in normal tissues and high expression in advanced cancers. To understand its physiological functions and identify the molecular mechanisms underlying these functions, we created mice with a gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tolg, Cornelia, Hamilton, Sara R., Nakrieko, Kerry-Ann, Kooshesh, Fatemeh, Walton, Paul, McCarthy, James B., Bissell, Mina J., Turley, Eva A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064710/ https://www.ncbi.nlm.nih.gov/pubmed/17158951 http://dx.doi.org/10.1083/jcb.200511027

Ejemplares similares

Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells
por: Veiseh, Mandana, et al.
Publicado: (2015)

Hyaluronan and RHAMM in Wound Repair and the “Cancerization” of Stromal Tissues
por: Tolg, Cornelia, et al.
Publicado: (2014)

RHAMM Is a Multifunctional Protein That Regulates Cancer Progression
por: Messam, Britney J., et al.
Publicado: (2021)

RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling
por: Tolg, Cornelia, et al.
Publicado: (2023)

Specific Sizes of Hyaluronan Oligosaccharides Stimulate Fibroblast Migration and Excisional Wound Repair
por: Tolg, Cornelia, et al.
Publicado: (2014)

Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation
por: Pibuel, Matías Arturo, et al.
Publicado: (2021)

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases
Publicado: (1996)

Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions
por: Vakonakis, Ioannis, et al.
Publicado: (2009)

CD28 Superagonist Shock and Blockage of Motogenic T Cell Cascade
por: Sundqvist, Karl-Gösta
Publicado: (2021)

The Roles of Hyaluronan/RHAMM/CD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression
por: Nikitovic, Dragana, et al.
Publicado: (2013)

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer
por: Misra, Suniti, et al.
Publicado: (2015)

RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast-like synoviocytes
por: Wu, Jing, et al.
Publicado: (2018)

Influence of anaesthetics on the production of cancer cell motogens, stromal cell-derived factor-1 and hepatocyte growth factor by fibroblasts
por: Gong, Wenjing, et al.
Publicado: (2021)

The Cytoskeletal Protein RHAMM and ERK1/2 Activity Maintain the Pluripotency of Murine Embryonic Stem Cells
por: Jiang, Jihong, et al.
Publicado: (2013)

A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites
por: Bhandage, Amol K, et al.
Publicado: (2020)

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
por: Tolg, Cornelia, et al.
Publicado: (2021)

Editorial: Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer
por: Naor, David
Publicado: (2016)

CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL)
por: Oldenburg, Darby, et al.
Publicado: (2016)

Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling
por: Song, Jung Min, et al.
Publicado: (2017)

Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment
por: Liu, Muhan, et al.
Publicado: (2019)

“RHAMM knockout” mice express a truncated RHAMM protein that promotes pancreatic cancer progression with dysfunctional p53
por: Chen, Xiang, et al.
Publicado: (2022)

Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens
por: Ivkovic, Sanja, et al.
Publicado: (2012)

Defects in the Palatine Organs
por: Bissell, M.
Publicado: (1874)

Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
por: Churin, Yuri, et al.
Publicado: (2003)

HGF/Met-Signaling Contributes to Immune Regulation by Modulating Tolerogenic and Motogenic Properties of Dendritic Cells
por: Hübel, Jessica, et al.
Publicado: (2015)

RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility
por: Li, Huaibiao, et al.
Publicado: (2015)

Increased RHAMM expression relates to ovarian cancer progression
por: Buttermore, Stephanie T., et al.
Publicado: (2017)

The role of RHAMM in cancer: Exposing novel therapeutic vulnerabilities
por: Hinneh, Josephine A., et al.
Publicado: (2022)

Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression
por: Choi, Soyoung, et al.
Publicado: (2019)

Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression
por: McCarthy, James B., et al.
Publicado: (2018)

RHAMM Expression in the Rat Endometrium during the Estrous Cycle and following Implantation
por: Ozbilgin, Kemal, et al.
Publicado: (2012)

RHAMM marks proliferative subpopulation of human colorectal cancer stem cells
por: Nakano, Michitaka, et al.
Publicado: (2023)

Corrigendum: Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression
por: McCarthy, James B., et al.
Publicado: (2018)

Tumor-Tissue Expression of the Hyaluronic Acid Receptor RHAMM Predicts Histological Transformation in Follicular Lymphoma Patients
por: Enemark, Marie Beck, et al.
Publicado: (2022)

RHAMM splice variants confer radiosensitivity in human breast cancer cell lines
por: Schütze, Alexandra, et al.
Publicado: (2016)

Categorisation of ventricular septal defects: review of the perimembranous morphology
por: McCarthy, KP, et al.
Publicado: (2000)

Galectin-3– and phospho-caveolin-1–dependent outside-in integrin signaling mediates the EGF motogenic response in mammary cancer cells
por: Boscher, Cecile, et al.
Publicado: (2013)

Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair
por: Matsuda, Chie, et al.
Publicado: (2015)

Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients
por: Bharat, Vinita, et al.
Publicado: (2021)

Defining the morphologic phenotypes of atrial septal defects and interatrial communications
por: McCarthy, KP, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_1f4j8kk0collulrntr77bkpup0