DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK...

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Detalles Bibliográficos
Autores principales: Weterings, Eric, Chen, David J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064754/
https://www.ncbi.nlm.nih.gov/pubmed/17938249
http://dx.doi.org/10.1083/jcb.200705106
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author Weterings, Eric
Chen, David J.
author_facet Weterings, Eric
Chen, David J.
author_sort Weterings, Eric
collection PubMed
description The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.
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spelling pubmed-20647542008-04-22 DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? Weterings, Eric Chen, David J. J Cell Biol Reviews The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair. The Rockefeller University Press 2007-10-22 /pmc/articles/PMC2064754/ /pubmed/17938249 http://dx.doi.org/10.1083/jcb.200705106 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Weterings, Eric
Chen, David J.
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
title DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
title_full DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
title_fullStr DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
title_full_unstemmed DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
title_short DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
title_sort dna-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064754/
https://www.ncbi.nlm.nih.gov/pubmed/17938249
http://dx.doi.org/10.1083/jcb.200705106
work_keys_str_mv AT weteringseric dnadependentproteinkinaseinnonhomologousendjoiningalockwithmultiplekeys
AT chendavidj dnadependentproteinkinaseinnonhomologousendjoiningalockwithmultiplekeys

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