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Are metacaspases caspases?

The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence t...

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Detalles Bibliográficos
Autores principales: Vercammen, Dominique, Declercq, Wim, Vandenabeele, Peter, Van Breusegem, Frank
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064784/
https://www.ncbi.nlm.nih.gov/pubmed/17967946
http://dx.doi.org/10.1083/jcb.200705193
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author Vercammen, Dominique
Declercq, Wim
Vandenabeele, Peter
Van Breusegem, Frank
author_facet Vercammen, Dominique
Declercq, Wim
Vandenabeele, Peter
Van Breusegem, Frank
author_sort Vercammen, Dominique
collection PubMed
description The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence that metacaspases lack caspase activity and that they are not responsible for the caspaselike activities detected during plant and fungal cell death. In this paper, we attempt to broaden the discussion of these peptidases to biological functions beyond apoptosis and cell death. We further suggest that metacaspases and paracaspases, although sharing structural and mechanistic features with the metazoan caspases, form a distinct family of clan CD cysteine peptidases.
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spelling pubmed-20647842008-05-05 Are metacaspases caspases? Vercammen, Dominique Declercq, Wim Vandenabeele, Peter Van Breusegem, Frank J Cell Biol Reviews The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence that metacaspases lack caspase activity and that they are not responsible for the caspaselike activities detected during plant and fungal cell death. In this paper, we attempt to broaden the discussion of these peptidases to biological functions beyond apoptosis and cell death. We further suggest that metacaspases and paracaspases, although sharing structural and mechanistic features with the metazoan caspases, form a distinct family of clan CD cysteine peptidases. The Rockefeller University Press 2007-11-05 /pmc/articles/PMC2064784/ /pubmed/17967946 http://dx.doi.org/10.1083/jcb.200705193 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Vercammen, Dominique
Declercq, Wim
Vandenabeele, Peter
Van Breusegem, Frank
Are metacaspases caspases?
title Are metacaspases caspases?
title_full Are metacaspases caspases?
title_fullStr Are metacaspases caspases?
title_full_unstemmed Are metacaspases caspases?
title_short Are metacaspases caspases?
title_sort are metacaspases caspases?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064784/
https://www.ncbi.nlm.nih.gov/pubmed/17967946
http://dx.doi.org/10.1083/jcb.200705193
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