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Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein

Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 inter...

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Autores principales: Rybkin, Igor I., Kim, Mi-Sung, Bezprozvannaya, Svetlana, Qi, Xiaoxia, Richardson, James A., Plato, Craig F., Hill, Joseph A., Bassel-Duby, Rhonda, Olson, Eric N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064797/
https://www.ncbi.nlm.nih.gov/pubmed/17984325
http://dx.doi.org/10.1083/jcb.200707101
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author Rybkin, Igor I.
Kim, Mi-Sung
Bezprozvannaya, Svetlana
Qi, Xiaoxia
Richardson, James A.
Plato, Craig F.
Hill, Joseph A.
Bassel-Duby, Rhonda
Olson, Eric N.
author_facet Rybkin, Igor I.
Kim, Mi-Sung
Bezprozvannaya, Svetlana
Qi, Xiaoxia
Richardson, James A.
Plato, Craig F.
Hill, Joseph A.
Bassel-Duby, Rhonda
Olson, Eric N.
author_sort Rybkin, Igor I.
collection PubMed
description Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca(2+)-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues.
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spelling pubmed-20647972008-05-05 Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein Rybkin, Igor I. Kim, Mi-Sung Bezprozvannaya, Svetlana Qi, Xiaoxia Richardson, James A. Plato, Craig F. Hill, Joseph A. Bassel-Duby, Rhonda Olson, Eric N. J Cell Biol Research Articles Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca(2+)-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues. The Rockefeller University Press 2007-11-05 /pmc/articles/PMC2064797/ /pubmed/17984325 http://dx.doi.org/10.1083/jcb.200707101 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Rybkin, Igor I.
Kim, Mi-Sung
Bezprozvannaya, Svetlana
Qi, Xiaoxia
Richardson, James A.
Plato, Craig F.
Hill, Joseph A.
Bassel-Duby, Rhonda
Olson, Eric N.
Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
title Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
title_full Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
title_fullStr Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
title_full_unstemmed Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
title_short Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
title_sort regulation of atrial natriuretic peptide secretion by a novel ras-like protein
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064797/
https://www.ncbi.nlm.nih.gov/pubmed/17984325
http://dx.doi.org/10.1083/jcb.200707101
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