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Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis

To examine the role of endothelial heparan sulfate during angiogenesis, we generated mice bearing an endothelial-targeted deletion in the biosynthetic enzyme N-acetylglucosamine N-deacetylase/N-sulfotransferase 1 (Ndst1). Physiological angiogenesis during cutaneous wound repair was unaffected, as wa...

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Detalles Bibliográficos
Autores principales:	Fuster, Mark M., Wang, Lianchun, Castagnola, Janice, Sikora, Lyudmila, Reddi, Krisanavane, Lee, Phillip H.A., Radek, Katherine A., Schuksz, Manuela, Bishop, Joseph R., Gallo, Richard L., Sriramarao, P., Esko, Jeffrey D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064806/ https://www.ncbi.nlm.nih.gov/pubmed/17470635 http://dx.doi.org/10.1083/jcb.200610086

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