LKB1 and AMPK maintain epithelial cell polarity under energetic stress

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LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5′monophosphate–activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarit...

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Detalles Bibliográficos
Autores principales: Mirouse, Vincent, Swick, Lance L., Kazgan, Nevzat, St Johnston, Daniel, Brenman, Jay E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064817/
https://www.ncbi.nlm.nih.gov/pubmed/17470638
http://dx.doi.org/10.1083/jcb.200702053
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