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An ACAP1-containing clathrin coat complex for endocytic recycling
Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064835/ https://www.ncbi.nlm.nih.gov/pubmed/17664335 http://dx.doi.org/10.1083/jcb.200608033 |
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author | Li, Jian Peters, Peter J. Bai, Ming Dai, Jun Bos, Erik Kirchhausen, Tomas Kandror, Konstantin V. Hsu, Victor W. |
author_facet | Li, Jian Peters, Peter J. Bai, Ming Dai, Jun Bos, Erik Kirchhausen, Tomas Kandror, Konstantin V. Hsu, Victor W. |
author_sort | Li, Jian |
collection | PubMed |
description | Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings, stimulation-dependent recycling of integrin that is critical for cell migration and insulin-stimulated recycling of glucose transporter type 4 (Glut4), which is required for glucose homeostasis. These findings not only advance a basic understanding of an early mechanistic step in endocytic recycling but also shed key mechanistic insights into major physiological events for which this transport plays a critical role. |
format | Text |
id | pubmed-2064835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-20648352008-01-30 An ACAP1-containing clathrin coat complex for endocytic recycling Li, Jian Peters, Peter J. Bai, Ming Dai, Jun Bos, Erik Kirchhausen, Tomas Kandror, Konstantin V. Hsu, Victor W. J Cell Biol Research Articles Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings, stimulation-dependent recycling of integrin that is critical for cell migration and insulin-stimulated recycling of glucose transporter type 4 (Glut4), which is required for glucose homeostasis. These findings not only advance a basic understanding of an early mechanistic step in endocytic recycling but also shed key mechanistic insights into major physiological events for which this transport plays a critical role. The Rockefeller University Press 2007-07-30 /pmc/articles/PMC2064835/ /pubmed/17664335 http://dx.doi.org/10.1083/jcb.200608033 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Research Articles Li, Jian Peters, Peter J. Bai, Ming Dai, Jun Bos, Erik Kirchhausen, Tomas Kandror, Konstantin V. Hsu, Victor W. An ACAP1-containing clathrin coat complex for endocytic recycling |
title | An ACAP1-containing clathrin coat complex for endocytic recycling |
title_full | An ACAP1-containing clathrin coat complex for endocytic recycling |
title_fullStr | An ACAP1-containing clathrin coat complex for endocytic recycling |
title_full_unstemmed | An ACAP1-containing clathrin coat complex for endocytic recycling |
title_short | An ACAP1-containing clathrin coat complex for endocytic recycling |
title_sort | acap1-containing clathrin coat complex for endocytic recycling |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064835/ https://www.ncbi.nlm.nih.gov/pubmed/17664335 http://dx.doi.org/10.1083/jcb.200608033 |
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