Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain

BACKGROUND: The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutations detected are short deletions in exon 19 or the L858R point mutation in exon...

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Detalles Bibliográficos
Autores principales: de Gunst, Matheus M, Gallegos-Ruiz, Marielle I, Giaccone, Giuseppe, Rodriguez, Jose Antonio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central|1 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064929/
https://www.ncbi.nlm.nih.gov/pubmed/17877814
http://dx.doi.org/10.1186/1476-4598-6-56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064929/
https://www.ncbi.nlm.nih.gov/pubmed/17877814
http://dx.doi.org/10.1186/1476-4598-6-56

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