Computational Methods for the Analysis of Array Comparative Genomic Hybridization

Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of high throughput data, which in turn has prompted the development of computational strategies for the ana...

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Detalles Bibliográficos
Autores principales: Chari, Raj, Lockwood, William W., Lam, Wan L.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2067254/
https://www.ncbi.nlm.nih.gov/pubmed/17992253
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author Chari, Raj
Lockwood, William W.
Lam, Wan L.
author_facet Chari, Raj
Lockwood, William W.
Lam, Wan L.
author_sort Chari, Raj
collection PubMed
description Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of high throughput data, which in turn has prompted the development of computational strategies for the analysis of array CGH data. Here we explain the principles behind array image processing, data visualization and genomic profile analysis, review currently available software packages, and raise considerations for future software development.
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spelling pubmed-20672542007-11-08 Computational Methods for the Analysis of Array Comparative Genomic Hybridization Chari, Raj Lockwood, William W. Lam, Wan L. Cancer Inform Articles Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of high throughput data, which in turn has prompted the development of computational strategies for the analysis of array CGH data. Here we explain the principles behind array image processing, data visualization and genomic profile analysis, review currently available software packages, and raise considerations for future software development. Libertas Academica 2007-02-10 /pmc/articles/PMC2067254/ /pubmed/17992253 Text en © 2006 The authors. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Articles
Chari, Raj
Lockwood, William W.
Lam, Wan L.
Computational Methods for the Analysis of Array Comparative Genomic Hybridization
title Computational Methods for the Analysis of Array Comparative Genomic Hybridization
title_full Computational Methods for the Analysis of Array Comparative Genomic Hybridization
title_fullStr Computational Methods for the Analysis of Array Comparative Genomic Hybridization
title_full_unstemmed Computational Methods for the Analysis of Array Comparative Genomic Hybridization
title_short Computational Methods for the Analysis of Array Comparative Genomic Hybridization
title_sort computational methods for the analysis of array comparative genomic hybridization
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2067254/
https://www.ncbi.nlm.nih.gov/pubmed/17992253
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AT lockwoodwilliamw computationalmethodsfortheanalysisofarraycomparativegenomichybridization
AT lamwanl computationalmethodsfortheanalysisofarraycomparativegenomichybridization

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