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Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila

Environmental stress (nutritive, chemical, electromagnetic and thermal) has been shown to disrupt central nervous system (CNS) development in every model system studied to date. However, empirical linkages between stress, specific targets in the brain, and consequences for behavior have rarely been...

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Detalles Bibliográficos
Autores principales: Wang, Xia, Green, David S., Roberts, Stephen P., de Belle, J. Steven
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2067990/
https://www.ncbi.nlm.nih.gov/pubmed/17992254
http://dx.doi.org/10.1371/journal.pone.0001125
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author Wang, Xia
Green, David S.
Roberts, Stephen P.
de Belle, J. Steven
author_facet Wang, Xia
Green, David S.
Roberts, Stephen P.
de Belle, J. Steven
author_sort Wang, Xia
collection PubMed
description Environmental stress (nutritive, chemical, electromagnetic and thermal) has been shown to disrupt central nervous system (CNS) development in every model system studied to date. However, empirical linkages between stress, specific targets in the brain, and consequences for behavior have rarely been established. The present study experimentally demonstrates one such linkage by examining the effects of ecologically-relevant thermal stress on development of the Drosophila melanogaster mushroom body (MB), a conserved sensory integration and associative center in the insect brain. We show that a daily hyperthermic episode throughout larval and pupal development (1) severely disrupts MB anatomy by reducing intrinsic Kenyon cell (KC) neuron numbers but has little effect on other brain structures or general anatomy, and (2) greatly impairs associative odor learning in adults, despite having little effect on memory or sensory acuity. Hence, heat stress of ecologically relevant duration and intensity can impair brain development and learning potential.
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spelling pubmed-20679902007-11-09 Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila Wang, Xia Green, David S. Roberts, Stephen P. de Belle, J. Steven PLoS One Research Article Environmental stress (nutritive, chemical, electromagnetic and thermal) has been shown to disrupt central nervous system (CNS) development in every model system studied to date. However, empirical linkages between stress, specific targets in the brain, and consequences for behavior have rarely been established. The present study experimentally demonstrates one such linkage by examining the effects of ecologically-relevant thermal stress on development of the Drosophila melanogaster mushroom body (MB), a conserved sensory integration and associative center in the insect brain. We show that a daily hyperthermic episode throughout larval and pupal development (1) severely disrupts MB anatomy by reducing intrinsic Kenyon cell (KC) neuron numbers but has little effect on other brain structures or general anatomy, and (2) greatly impairs associative odor learning in adults, despite having little effect on memory or sensory acuity. Hence, heat stress of ecologically relevant duration and intensity can impair brain development and learning potential. Public Library of Science 2007-11-07 /pmc/articles/PMC2067990/ /pubmed/17992254 http://dx.doi.org/10.1371/journal.pone.0001125 Text en Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Xia
Green, David S.
Roberts, Stephen P.
de Belle, J. Steven
Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila
title Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila
title_full Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila
title_fullStr Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila
title_full_unstemmed Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila
title_short Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila
title_sort thermal disruption of mushroom body development and odor learning in drosophila
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2067990/
https://www.ncbi.nlm.nih.gov/pubmed/17992254
http://dx.doi.org/10.1371/journal.pone.0001125
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