Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells

BACKGROUND: Polychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both. OBJECTIVE: Our objective was to identify individual PCBs that directly affect TH signaling by acting on the TR. ME...

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Detalles Bibliográficos
Autores principales: Gauger, Kelly J., Giera, Stefanie, Sharlin, David S., Bansal, Ruby, Iannacone, Eric, Zoeller, R. Thomas
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072832/
https://www.ncbi.nlm.nih.gov/pubmed/18007995
http://dx.doi.org/10.1289/ehp.10328

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