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Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort

BACKGROUND AND OBJECTIVES: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM(2.5) (fine-particulate air pollution of < 2.5 μm in aerodynamic diameter) on heart rate variability (HRV) in a cross-sec...

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Autores principales: Chahine, Teresa, Baccarelli, Andrea, Litonjua, Augusto, Wright, Robert O., Suh, Helen, Gold, Diane R., Sparrow, David, Vokonas, Pantel, Schwartz, Joel
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072834/
https://www.ncbi.nlm.nih.gov/pubmed/18007994
http://dx.doi.org/10.1289/ehp.10318
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author Chahine, Teresa
Baccarelli, Andrea
Litonjua, Augusto
Wright, Robert O.
Suh, Helen
Gold, Diane R.
Sparrow, David
Vokonas, Pantel
Schwartz, Joel
author_facet Chahine, Teresa
Baccarelli, Andrea
Litonjua, Augusto
Wright, Robert O.
Suh, Helen
Gold, Diane R.
Sparrow, David
Vokonas, Pantel
Schwartz, Joel
author_sort Chahine, Teresa
collection PubMed
description BACKGROUND AND OBJECTIVES: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM(2.5) (fine-particulate air pollution of < 2.5 μm in aerodynamic diameter) on heart rate variability (HRV) in a cross-sectional analysis of the Normative Aging Study, an elderly cohort. We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter. METHODS: HRV measurements were taken on 539 subjects. Linear mixed effects models were fit for the logarithm of HRV metrics—including standard deviation of normal-to-normal intervals (SDNN), high frequency (HF), and low frequency (LF)—and PM(2.5) concentrations in the 48 hr preceding HRV measurement, controlling for confounders and a random subject effect. RESULTS: PM(2.5) was significantly associated with SDNN (p = 0.04) and HF (p = 0.03) in all subjects. There was no association in subjects with GSTM1, whereas there was a significant association with SDNN, HF, and LF in subjects with the deletion. Similarly, there was no association with any HRV measure in subjects with the short repeat variant of HMOX-1, and significant associations in subjects with any long repeat. We found a significant three-way interaction of PM(2.5) with GSTM1 and HMOX-1 determining SDNN (p = 0.008), HF (p = 0.01) and LF (p = 0.04). In subjects with the GSTM1 deletion and the HMOX-1 long repeat, SDNN decreased by 13% [95% confidence interval (CI), −21% to −4%], HF decreased by 28% (95% CI, −43% to −9%), and LF decreased by 20% (95% CI, −35% to −3%) per 10 μg/m(3) increase in PM. CONCLUSIONS: Oxidative stress is an important pathway for the autonomic effects of particles.
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spelling pubmed-20728342007-11-14 Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort Chahine, Teresa Baccarelli, Andrea Litonjua, Augusto Wright, Robert O. Suh, Helen Gold, Diane R. Sparrow, David Vokonas, Pantel Schwartz, Joel Environ Health Perspect Research BACKGROUND AND OBJECTIVES: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM(2.5) (fine-particulate air pollution of < 2.5 μm in aerodynamic diameter) on heart rate variability (HRV) in a cross-sectional analysis of the Normative Aging Study, an elderly cohort. We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter. METHODS: HRV measurements were taken on 539 subjects. Linear mixed effects models were fit for the logarithm of HRV metrics—including standard deviation of normal-to-normal intervals (SDNN), high frequency (HF), and low frequency (LF)—and PM(2.5) concentrations in the 48 hr preceding HRV measurement, controlling for confounders and a random subject effect. RESULTS: PM(2.5) was significantly associated with SDNN (p = 0.04) and HF (p = 0.03) in all subjects. There was no association in subjects with GSTM1, whereas there was a significant association with SDNN, HF, and LF in subjects with the deletion. Similarly, there was no association with any HRV measure in subjects with the short repeat variant of HMOX-1, and significant associations in subjects with any long repeat. We found a significant three-way interaction of PM(2.5) with GSTM1 and HMOX-1 determining SDNN (p = 0.008), HF (p = 0.01) and LF (p = 0.04). In subjects with the GSTM1 deletion and the HMOX-1 long repeat, SDNN decreased by 13% [95% confidence interval (CI), −21% to −4%], HF decreased by 28% (95% CI, −43% to −9%), and LF decreased by 20% (95% CI, −35% to −3%) per 10 μg/m(3) increase in PM. CONCLUSIONS: Oxidative stress is an important pathway for the autonomic effects of particles. National Institute of Environmental Health Sciences 2007-11 2007-08-20 /pmc/articles/PMC2072834/ /pubmed/18007994 http://dx.doi.org/10.1289/ehp.10318 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Chahine, Teresa
Baccarelli, Andrea
Litonjua, Augusto
Wright, Robert O.
Suh, Helen
Gold, Diane R.
Sparrow, David
Vokonas, Pantel
Schwartz, Joel
Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
title Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
title_full Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
title_fullStr Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
title_full_unstemmed Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
title_short Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
title_sort particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072834/
https://www.ncbi.nlm.nih.gov/pubmed/18007994
http://dx.doi.org/10.1289/ehp.10318
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