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Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort

BACKGROUND: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, persistent organic pollutants widely spread throughout the environment and human populations. They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in hum...

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Detalles Bibliográficos
Autores principales: Fei, Chunyuan, McLaughlin, Joseph K., Tarone, Robert E., Olsen, Jørn
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072850/
https://www.ncbi.nlm.nih.gov/pubmed/18008003
http://dx.doi.org/10.1289/ehp.10506
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author Fei, Chunyuan
McLaughlin, Joseph K.
Tarone, Robert E.
Olsen, Jørn
author_facet Fei, Chunyuan
McLaughlin, Joseph K.
Tarone, Robert E.
Olsen, Jørn
author_sort Fei, Chunyuan
collection PubMed
description BACKGROUND: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, persistent organic pollutants widely spread throughout the environment and human populations. They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in humans is uncertain. OBJECTIVES: We investigated the association between plasma levels of PFOS and PFOA in pregnant women and their infants’ birth weight and length of gestation. METHODS: We randomly selected 1,400 women and their infants from the Danish National Birth Cohort among those who completed all four computer-assisted telephone interviews, provided the first blood samples between gestational weeks 4 and 14, and who gave birth to a single live-born child without congenital malformation. PFOS and PFOA were measured by high performance liquid chromatography–tandem mass spectrometer. RESULTS: PFOS and PFOA levels in maternal plasma were on average 35.3 and 5.6 ng/mL, respectively. Only PFOA levels were inversely associated with birth weight (adjusted β = −10.63 g; 95% confidence interval, −20.79 to −0.47 g). Neither maternal PFOS nor PFOA levels were consistently associated with the risk for preterm birth or low birth weight. We observed no adverse effects for maternal PFOS or PFOA levels on small for gestational age. CONCLUSION: Our nationwide cohort data suggest an inverse association between maternal plasma PFOA levels and birth weight. Because of widespread exposure to these chemicals, our findings may be of potential public health concern.
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spelling pubmed-20728502007-11-14 Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort Fei, Chunyuan McLaughlin, Joseph K. Tarone, Robert E. Olsen, Jørn Environ Health Perspect Research BACKGROUND: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, persistent organic pollutants widely spread throughout the environment and human populations. They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in humans is uncertain. OBJECTIVES: We investigated the association between plasma levels of PFOS and PFOA in pregnant women and their infants’ birth weight and length of gestation. METHODS: We randomly selected 1,400 women and their infants from the Danish National Birth Cohort among those who completed all four computer-assisted telephone interviews, provided the first blood samples between gestational weeks 4 and 14, and who gave birth to a single live-born child without congenital malformation. PFOS and PFOA were measured by high performance liquid chromatography–tandem mass spectrometer. RESULTS: PFOS and PFOA levels in maternal plasma were on average 35.3 and 5.6 ng/mL, respectively. Only PFOA levels were inversely associated with birth weight (adjusted β = −10.63 g; 95% confidence interval, −20.79 to −0.47 g). Neither maternal PFOS nor PFOA levels were consistently associated with the risk for preterm birth or low birth weight. We observed no adverse effects for maternal PFOS or PFOA levels on small for gestational age. CONCLUSION: Our nationwide cohort data suggest an inverse association between maternal plasma PFOA levels and birth weight. Because of widespread exposure to these chemicals, our findings may be of potential public health concern. National Institute of Environmental Health Sciences 2007-11 2007-08-16 /pmc/articles/PMC2072850/ /pubmed/18008003 http://dx.doi.org/10.1289/ehp.10506 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Fei, Chunyuan
McLaughlin, Joseph K.
Tarone, Robert E.
Olsen, Jørn
Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
title Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
title_full Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
title_fullStr Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
title_full_unstemmed Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
title_short Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
title_sort perfluorinated chemicals and fetal growth: a study within the danish national birth cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072850/
https://www.ncbi.nlm.nih.gov/pubmed/18008003
http://dx.doi.org/10.1289/ehp.10506
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