Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease

Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborative efforts are needed to better characterize clinical and prognostic parameters and to des...

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Autores principales: Rubin, Lewis J, Black, Carol M, Denton, Christopher P, Seibold, James R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central|1 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072884/
https://www.ncbi.nlm.nih.gov/pubmed/17767739
http://dx.doi.org/10.1186/ar2194
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author Rubin, Lewis J
Black, Carol M
Denton, Christopher P
Seibold, James R
author_facet Rubin, Lewis J
Black, Carol M
Denton, Christopher P
Seibold, James R
author_sort Rubin, Lewis J
collection PubMed
description Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborative efforts are needed to better characterize clinical and prognostic parameters and to design and implement large-scale clinical trials in well defined populations with therapies that target potential disease modulators.
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spelling pubmed-20728842007-11-10 Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease Rubin, Lewis J Black, Carol M Denton, Christopher P Seibold, James R Arthritis Res Ther Review Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborative efforts are needed to better characterize clinical and prognostic parameters and to design and implement large-scale clinical trials in well defined populations with therapies that target potential disease modulators. BioMed Central|1 2007 2007-08-15 /pmc/articles/PMC2072884/ /pubmed/17767739 http://dx.doi.org/10.1186/ar2194 Text en Copyright © 2007 BioMed Central Ltd
spellingShingle Review
Rubin, Lewis J
Black, Carol M
Denton, Christopher P
Seibold, James R
Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
title Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
title_full Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
title_fullStr Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
title_full_unstemmed Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
title_short Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
title_sort clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072884/
https://www.ncbi.nlm.nih.gov/pubmed/17767739
http://dx.doi.org/10.1186/ar2194
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