New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile

A new series of 2,6,9-trisubstituted adenines (5–14) have been prepared and evaluated in radioligand binding studies for their affinity at the human A(1), A(2A) and A(3) adenosine receptors and in adenylyl cyclase experiments for their potency at the human A(2B) subtype. From this preliminary study...

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Detalles Bibliográficos
Autores principales: Lambertucci, Catia, Cristalli, Gloria, Dal Ben, Diego, Kachare, Dhuldeo D., Bolcato, Chiara, Klotz, Karl-Norbert, Spalluto, Giampiero, Volpini, Rosaria
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2007
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072915/
https://www.ncbi.nlm.nih.gov/pubmed/18404447
http://dx.doi.org/10.1007/s11302-007-9068-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072915/
https://www.ncbi.nlm.nih.gov/pubmed/18404447
http://dx.doi.org/10.1007/s11302-007-9068-9

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