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Breast cancer incidence subsequent to surgical reduction of the female breast.
The incidence of breast cancer among 1240 women who were treated surgically for breast hypertrophy in Copenhagen, Denmark between 1943 and 1971 was determined and compared with age- and calendar period-specific rates for the Danish female population. A total of 32 cases of breast cancer had develope...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1996
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074248/ https://www.ncbi.nlm.nih.gov/pubmed/8611415 |
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author | Baasch, M. Nielsen, S. F. Engholm, G. Lund, K. |
author_facet | Baasch, M. Nielsen, S. F. Engholm, G. Lund, K. |
author_sort | Baasch, M. |
collection | PubMed |
description | The incidence of breast cancer among 1240 women who were treated surgically for breast hypertrophy in Copenhagen, Denmark between 1943 and 1971 was determined and compared with age- and calendar period-specific rates for the Danish female population. A total of 32 cases of breast cancer had developed by the end of 1990; the expected number was 52.55, yielding a relative risk (RR) of 0.61 [95% confidence interval (CI) 0.42-0.86]. The greatest reduction in risk was observed for women who had 600 g or more of breast tissue removed (RR=0.30; 95% CI 0.10-0.69). This suggests that the number of potential foci is important for cancer development in the female breast. In the group of women who were operated on before the age of 20, four cases of breast cancer developed, compared with 2.23 expected cases, to give an RR of 1.79, suggesting that the aetiology of their breast hypertrophy may be different from that for the rest of the group. |
format | Text |
id | pubmed-2074248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20742482009-09-10 Breast cancer incidence subsequent to surgical reduction of the female breast. Baasch, M. Nielsen, S. F. Engholm, G. Lund, K. Br J Cancer Research Article The incidence of breast cancer among 1240 women who were treated surgically for breast hypertrophy in Copenhagen, Denmark between 1943 and 1971 was determined and compared with age- and calendar period-specific rates for the Danish female population. A total of 32 cases of breast cancer had developed by the end of 1990; the expected number was 52.55, yielding a relative risk (RR) of 0.61 [95% confidence interval (CI) 0.42-0.86]. The greatest reduction in risk was observed for women who had 600 g or more of breast tissue removed (RR=0.30; 95% CI 0.10-0.69). This suggests that the number of potential foci is important for cancer development in the female breast. In the group of women who were operated on before the age of 20, four cases of breast cancer developed, compared with 2.23 expected cases, to give an RR of 1.79, suggesting that the aetiology of their breast hypertrophy may be different from that for the rest of the group. Nature Publishing Group 1996-04 /pmc/articles/PMC2074248/ /pubmed/8611415 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Baasch, M. Nielsen, S. F. Engholm, G. Lund, K. Breast cancer incidence subsequent to surgical reduction of the female breast. |
title | Breast cancer incidence subsequent to surgical reduction of the female breast. |
title_full | Breast cancer incidence subsequent to surgical reduction of the female breast. |
title_fullStr | Breast cancer incidence subsequent to surgical reduction of the female breast. |
title_full_unstemmed | Breast cancer incidence subsequent to surgical reduction of the female breast. |
title_short | Breast cancer incidence subsequent to surgical reduction of the female breast. |
title_sort | breast cancer incidence subsequent to surgical reduction of the female breast. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074248/ https://www.ncbi.nlm.nih.gov/pubmed/8611415 |
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