Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.

Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little informatio...

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Autores principales: Agrez, M. V., Bates, R. C., Mitchell, D., Wilson, N., Ferguson, N., Anseline, P., Sheppard, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074269/
https://www.ncbi.nlm.nih.gov/pubmed/8611401
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author Agrez, M. V.
Bates, R. C.
Mitchell, D.
Wilson, N.
Ferguson, N.
Anseline, P.
Sheppard, D.
author_facet Agrez, M. V.
Bates, R. C.
Mitchell, D.
Wilson, N.
Ferguson, N.
Anseline, P.
Sheppard, D.
author_sort Agrez, M. V.
collection PubMed
description Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer. IMAGES:
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spelling pubmed-20742692009-09-10 Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer. Agrez, M. V. Bates, R. C. Mitchell, D. Wilson, N. Ferguson, N. Anseline, P. Sheppard, D. Br J Cancer Research Article Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer. IMAGES: Nature Publishing Group 1996-04 /pmc/articles/PMC2074269/ /pubmed/8611401 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Agrez, M. V.
Bates, R. C.
Mitchell, D.
Wilson, N.
Ferguson, N.
Anseline, P.
Sheppard, D.
Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
title Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
title_full Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
title_fullStr Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
title_full_unstemmed Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
title_short Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
title_sort multiplicity of fibronectin-binding alpha v integrin receptors in colorectal cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074269/
https://www.ncbi.nlm.nih.gov/pubmed/8611401
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