Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.

A total of 80 primary human breast carcinoma DNAs were analysed for loss of heterozygosity (LOH) on the long arm of chromosome 6, using microsatellite markers whose location has been defined physically and by linkage analysis. Loss of heterozygosity was observed in 38 of 80 (48%) tumours that were i...

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Autores principales: Sheng, Z. M., Marchetti, A., Buttitta, F., Champeme, M. H., Campani, D., Bistocchi, M., Lidereau, R., Callahan, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074311/
https://www.ncbi.nlm.nih.gov/pubmed/8546898
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author Sheng, Z. M.
Marchetti, A.
Buttitta, F.
Champeme, M. H.
Campani, D.
Bistocchi, M.
Lidereau, R.
Callahan, R.
author_facet Sheng, Z. M.
Marchetti, A.
Buttitta, F.
Champeme, M. H.
Campani, D.
Bistocchi, M.
Lidereau, R.
Callahan, R.
author_sort Sheng, Z. M.
collection PubMed
description A total of 80 primary human breast carcinoma DNAs were analysed for loss of heterozygosity (LOH) on the long arm of chromosome 6, using microsatellite markers whose location has been defined physically and by linkage analysis. Loss of heterozygosity was observed in 38 of 80 (48%) tumours that were informative for at least one locus. The analysis revealed partial or interstitial deletions of chromosome 6q. Detailed mapping of chromosome 6q in these tumour DNAs identified two and perhaps three commonly deleted regions. One of these is located between markers D6S251 and D6S252 (6q14-q16.2), another between D6S268 and D6S261 (6q16.3-q23) and a third between D6S287 and D6S270 (6q22.3-q23.1). IMAGES:
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spelling pubmed-20743112009-09-10 Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas. Sheng, Z. M. Marchetti, A. Buttitta, F. Champeme, M. H. Campani, D. Bistocchi, M. Lidereau, R. Callahan, R. Br J Cancer Research Article A total of 80 primary human breast carcinoma DNAs were analysed for loss of heterozygosity (LOH) on the long arm of chromosome 6, using microsatellite markers whose location has been defined physically and by linkage analysis. Loss of heterozygosity was observed in 38 of 80 (48%) tumours that were informative for at least one locus. The analysis revealed partial or interstitial deletions of chromosome 6q. Detailed mapping of chromosome 6q in these tumour DNAs identified two and perhaps three commonly deleted regions. One of these is located between markers D6S251 and D6S252 (6q14-q16.2), another between D6S268 and D6S261 (6q16.3-q23) and a third between D6S287 and D6S270 (6q22.3-q23.1). IMAGES: Nature Publishing Group 1996-01 /pmc/articles/PMC2074311/ /pubmed/8546898 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sheng, Z. M.
Marchetti, A.
Buttitta, F.
Champeme, M. H.
Campani, D.
Bistocchi, M.
Lidereau, R.
Callahan, R.
Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
title Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
title_full Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
title_fullStr Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
title_full_unstemmed Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
title_short Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
title_sort multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074311/
https://www.ncbi.nlm.nih.gov/pubmed/8546898
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