Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.

Thirty-four cases of ductal carcinoma in situ (DCIS) of the breast, with or without associated benign or invasive disease, were analysed for allelic imbalance (AI) in the region of the BRCA1 gene. AI on 17q12-23 in DCIS was demonstrated in 74% of cases, and in the majority of cases the region of AI...

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Autores principales: Munn, K. E., Walker, R. A., Menasce, L., Varley, J. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074329/
https://www.ncbi.nlm.nih.gov/pubmed/8605099
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author Munn, K. E.
Walker, R. A.
Menasce, L.
Varley, J. M.
author_facet Munn, K. E.
Walker, R. A.
Menasce, L.
Varley, J. M.
author_sort Munn, K. E.
collection PubMed
description Thirty-four cases of ductal carcinoma in situ (DCIS) of the breast, with or without associated benign or invasive disease, were analysed for allelic imbalance (AI) in the region of the BRCA1 gene. AI on 17q12-23 in DCIS was demonstrated in 74% of cases, and in the majority of cases the region of AI included the BRCA1 gene. However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q. IMAGES:
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spelling pubmed-20743292009-09-10 Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast. Munn, K. E. Walker, R. A. Menasce, L. Varley, J. M. Br J Cancer Research Article Thirty-four cases of ductal carcinoma in situ (DCIS) of the breast, with or without associated benign or invasive disease, were analysed for allelic imbalance (AI) in the region of the BRCA1 gene. AI on 17q12-23 in DCIS was demonstrated in 74% of cases, and in the majority of cases the region of AI included the BRCA1 gene. However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q. IMAGES: Nature Publishing Group 1996-03 /pmc/articles/PMC2074329/ /pubmed/8605099 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Munn, K. E.
Walker, R. A.
Menasce, L.
Varley, J. M.
Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
title Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
title_full Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
title_fullStr Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
title_full_unstemmed Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
title_short Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
title_sort allelic imbalance in the region of the brca1 gene in ductal carcinoma in situ of the breast.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074329/
https://www.ncbi.nlm.nih.gov/pubmed/8605099
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AT menascel allelicimbalanceintheregionofthebrca1geneinductalcarcinomainsituofthebreast
AT varleyjm allelicimbalanceintheregionofthebrca1geneinductalcarcinomainsituofthebreast

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