Genetic determinants of cutaneous malignant melanoma in Sinclair swine.

The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclai...

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Autores principales: Blangero, J., Tissot, R. G., Beattie, C. W., Amoss, M. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074359/
https://www.ncbi.nlm.nih.gov/pubmed/8605105
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author Blangero, J.
Tissot, R. G.
Beattie, C. W.
Amoss, M. S.
author_facet Blangero, J.
Tissot, R. G.
Beattie, C. W.
Amoss, M. S.
author_sort Blangero, J.
collection PubMed
description The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leukocyte antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden.
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spelling pubmed-20743592009-09-10 Genetic determinants of cutaneous malignant melanoma in Sinclair swine. Blangero, J. Tissot, R. G. Beattie, C. W. Amoss, M. S. Br J Cancer Research Article The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leukocyte antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden. Nature Publishing Group 1996-03 /pmc/articles/PMC2074359/ /pubmed/8605105 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Blangero, J.
Tissot, R. G.
Beattie, C. W.
Amoss, M. S.
Genetic determinants of cutaneous malignant melanoma in Sinclair swine.
title Genetic determinants of cutaneous malignant melanoma in Sinclair swine.
title_full Genetic determinants of cutaneous malignant melanoma in Sinclair swine.
title_fullStr Genetic determinants of cutaneous malignant melanoma in Sinclair swine.
title_full_unstemmed Genetic determinants of cutaneous malignant melanoma in Sinclair swine.
title_short Genetic determinants of cutaneous malignant melanoma in Sinclair swine.
title_sort genetic determinants of cutaneous malignant melanoma in sinclair swine.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074359/
https://www.ncbi.nlm.nih.gov/pubmed/8605105
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