Cargando…
Frequent gene deletions in potentially malignant oral lesions.
Some oral cancers are preceded by premalignant lesions which include leucoplakia and erythroplakia. At present there are no reliable markers to identify lesions that may progress to malignancy. We have analysed 30 potentially malignant oral lesions for deletions at chromosomal regions that harbour t...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1996
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074383/ https://www.ncbi.nlm.nih.gov/pubmed/8611386 |
_version_ | 1782137955266068480 |
---|---|
author | Emilion, G. Langdon, J. D. Speight, P. Partridge, M. |
author_facet | Emilion, G. Langdon, J. D. Speight, P. Partridge, M. |
author_sort | Emilion, G. |
collection | PubMed |
description | Some oral cancers are preceded by premalignant lesions which include leucoplakia and erythroplakia. At present there are no reliable markers to identify lesions that may progress to malignancy. We have analysed 30 potentially malignant oral lesions for deletions at chromosomal regions that harbour tumour-suppressor genes for oral cancer. A total of 16 of 30 cases (53%) showed loss of heterozygosity (LOH) or allele imbalance at TP53, DCC, 3p21.3-22.1 or 3p12.1-13. These genetic alterations were detected in dysplastic lesions but not in histologically normal mucosa and may be early events in the carcinogenic process. A total of 64% of dysplastic lesions that recurred during the study showed LOH or allele imbalance in the initial biopsy and the number of genetic abnormalities increased in the tumours that developed. This type of molecular profiling may help to identify patients with lesions that may recur or acquire additional genetic events and progress to malignancy. IMAGES: |
format | Text |
id | pubmed-2074383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20743832009-09-10 Frequent gene deletions in potentially malignant oral lesions. Emilion, G. Langdon, J. D. Speight, P. Partridge, M. Br J Cancer Research Article Some oral cancers are preceded by premalignant lesions which include leucoplakia and erythroplakia. At present there are no reliable markers to identify lesions that may progress to malignancy. We have analysed 30 potentially malignant oral lesions for deletions at chromosomal regions that harbour tumour-suppressor genes for oral cancer. A total of 16 of 30 cases (53%) showed loss of heterozygosity (LOH) or allele imbalance at TP53, DCC, 3p21.3-22.1 or 3p12.1-13. These genetic alterations were detected in dysplastic lesions but not in histologically normal mucosa and may be early events in the carcinogenic process. A total of 64% of dysplastic lesions that recurred during the study showed LOH or allele imbalance in the initial biopsy and the number of genetic abnormalities increased in the tumours that developed. This type of molecular profiling may help to identify patients with lesions that may recur or acquire additional genetic events and progress to malignancy. IMAGES: Nature Publishing Group 1996-03 /pmc/articles/PMC2074383/ /pubmed/8611386 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Emilion, G. Langdon, J. D. Speight, P. Partridge, M. Frequent gene deletions in potentially malignant oral lesions. |
title | Frequent gene deletions in potentially malignant oral lesions. |
title_full | Frequent gene deletions in potentially malignant oral lesions. |
title_fullStr | Frequent gene deletions in potentially malignant oral lesions. |
title_full_unstemmed | Frequent gene deletions in potentially malignant oral lesions. |
title_short | Frequent gene deletions in potentially malignant oral lesions. |
title_sort | frequent gene deletions in potentially malignant oral lesions. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074383/ https://www.ncbi.nlm.nih.gov/pubmed/8611386 |
work_keys_str_mv | AT emiliong frequentgenedeletionsinpotentiallymalignantorallesions AT langdonjd frequentgenedeletionsinpotentiallymalignantorallesions AT speightp frequentgenedeletionsinpotentiallymalignantorallesions AT partridgem frequentgenedeletionsinpotentiallymalignantorallesions |